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Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2024, vol. 30, issue4
Subject Area: Medicine
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DOI: 10.5272/jimab.2024304.5824
Published online: 22 October 2024
Original article
J of IMAB. 2024 Oct-Dec;30(4):5824-5828
VALUE OF AMINOTRANSFERASES IN LIVER CIRRHOSIS
Miroslava Mihaylova1
, Strahil Strashilov2, Pencho Tonchev3,
1) Department of Gastroenterology, Nephrology and Hematology, Faculty of Medicine, Medical University of Pleven, University Hospital Georgi Stranski Pleven, Bulgaria.
2) Department of Plastic Restorative, Reconstructive and Aesthetic Surgery, Medical University Pleven, Bulgaria.
3) Department of Surgical Nursing Care, Faculty of Health Care, Medical University of Pleven, Bulgaria.
ABSTRACT:
Aim: To ditermine values of ASAT and ALAT and their ratio in different stages of liver cirrhosis.
Material and methods: A retrospective study was conducted, including patients with newly diagnosed liver cirrhosis from 01.01. 2017 to 31.12. 2021. Of all, 258 (71%) were men and 103 (29%) were women. The mean age of the study population was 57±11.4 years, with alcohol as the leading etiology in 262 (72.6%) of all cases. AT were measured at an upper reference limit of 40UI/ml. All were staged by Child-Pough and MELD Na score. IBM SPSS 26 and Excel statistics for data processing were used at a significant level of p< 0.05.
Results: Of all 361 individuals, normal AT were measured at 89 (24.7%), at 96 (25.76%) only with normal ASAT and at 233 (66.77%) only with normal ALAT. The mean value of ASAT increases significantly depending on the Child stage (p=.004) and is close to the significance of MELD Na (p=.036). Mean ALAT values were minimal to moderately elevated, with no significant association with them (p=.647, p=.020). 90% of individuals had an ASAT/ALAT ratio above 1, which showed substantial dependence on Child and MELD Na (p=.000, p=.000). A ratio above 2 was found at 194 (53.7%) mainly in Child C, which was associated with alcohol etiology.
Conclusion: The absolute values of ASAT and ALAT have no relationship with the severity of liver cirrhosis, unlike their ratio, which significantly increases.
Keywords: Aminotransferases, liver, Child-Pough, MELD Na,
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Please cite this article as: Mihaylova M, Strashilov S, Tonchev P. Value of Aminotransferases in Liver cirrhosis. J of IMAB. 2024 Oct-Dec;30(4):5824-5828. [Crossref - 10.5272/jimab.2024304.5824]
Correspondence to: Miroslava Ivanova Mihaylova, Department of Gastroenterology, Nephrology and Hematology, Faculty of Medicine, Medical University of Pleven; 8A, Georgi Kochev Blvd., Pleven 5800, Bulgaria; E-mail: mihailova75.md@gmail.com
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Received: 20 May 2024
Published online: 22 October 2024