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Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2025, vol. 31, issue2
Subject Area: Dental Medicine
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DOI: 10.5272/jimab.2025312.6116
Published online: 07 April 2025
Original article
J of IMAB. 2025 Apr-Jun;31(2):6116-6123
EFFECT OF XYLITOL ON PLAQUE INDEX AND ACIDITY OF DENTAL BIOFILM AND SALIVA
Ralitsa Bogovska-Gigova
, Krasimir Hristov,
Department of Pediatric Dentistry, Faculty of Dental Medicine, Medical University, Sofia, Bulgaria.
ABSTRACT:
Introduction: Dental caries is the most common oral disease in childhood, and sucrose plays a significant role in its development. As awareness grows of the health implications surrounding high sugar diets, finding appropriate sugar substitutes becomes crucial. One of the used substitutes is xylitol - a sugar alcohol used as a sweetener. The aim of this study was to evaluate and compare the effects of using xylitol lollipops in children aged 7 to 12 years on the formation and accumulation of dental biofilm, the pH value of dental biofilm, and the pH value of saliva.
Materials and methods: The study involved 40 children aged 7 to 12. The value of the plaque index, the pH of the saliva, and plaque were evaluated after 14-day frequent usage of xylitol lollipops.
Results: The results show that the use of xylitol lollipops reduces the values of the plaque index. Xylitol products have been shown to potentially increase plaque and saliva pH values. The differences are statistically significant compared to the baseline levels (p<0.001).
Conclusion: These findings collectively suggest that xylitol effectively reduces plaque accumulation and maintains a favorable pH environment in the oral cavity, which can help prevent dental caries and improve overall oral health. Such products are a valuable preventive measure among schoolchildren and can replace the use of sugar-containing lollipops.
Keywords: Ipreventive measures, xylitol, xylitol lollipops, pH of dental biofilm, pH of saliva,
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Please cite this article as: Bogovska-Gigova R, Hristov K. Effect of Xylitol on Plaque Index and Acidity of Dental Biofilm and Saliva. J of IMAB. 2025 Apr-Jun;31(2):6116-6123. [Crossref - 10.5272/jimab.2025312.6116]
Correspondence to: Ralitsa Bogovska-Gigova, Department of Pediatric Dentistry, Faculty of Dental Medicine, Medical University – Sofia; 1, Georgi Sofiisky Str., Sofia, Bulgaria; E-mail: r.bogovska@fdm.mu-sofia.bg
REFERENCES:
1. Aggarwal C, Sandhu M, Sachdev V, Dayal G, Prabhu N, Issrani R. Prevalence of dental caries and dental fluorosis among 7-12-year-old school children in an Indian subpopulation: A cross-sectional study. Pesqui Bras Odontopediatria Clнn Integr. 2021; 21:e0141:1–9. [Crossref]
2. Ray RR. Dental biofilm: Risks, diagnostics and management. Biocatal Agric Biotechnol. 2022 Aug;43:102381. [Crossref]
3. Proctor DM, Shelef KM, Gonzalez A, Davis CL, Dethlefsen L, Burns AR, et al. Microbial biogeography and ecology of the mouth and implications for periodontal diseases. Periodontol 2000. 2020 Feb;82(1):26-41. [PubMed]
4. Riley P, Moore D, Ahmed F, Sharif MO, Worthington HV. Xylitol-containing products for preventing dental caries in children and adults. Cochrane Database Syst Rev. 2015 Mar 26;2015(3):CD010743. [PubMed]
5. Ahuja V, Macho M, Ewe D, Singh M, Saha S, Saurav K. Biological and Pharmacological Potential of Xylitol: A Molecular Insight of Unique Metabolism. Foods. 2020 Nov 2;9(11):1592. [PubMed]
6. Wölnerhanssen BK, Meyer-Gerspach AC, Beglinger C, Islam MS. Metabolic effects of the natural sweeteners xylitol and erythritol: A comprehensive review. Crit Rev Food Sci Nutr. 2020;60(12):1986-1998. [PubMed]
7. Kõljalg S, Smidt I, Chakrabarti A, Bosscher D, Mändar R. Exploration of singular and synergistic effect of xylitol and erythritol on causative agents of dental caries. Sci Rep. 2020;10(1):6297. [PubMed]
8. Seki M, Karakama F, Kawato T, Tanaka H, Saeki Y, Yamashita Y. Effect of xylitol gum on the level of oral mutans streptococci of preschoolers: block-randomized trial. Int Dent J. 2011;61(5):274-280. [PubMed]
9. Miyasawa H, Iwami Y, Mayanagi H, Takahashi N. Xylitol inhibition of anaerobic acid production by Streptococcus mutans at various pH levels. Oral Microbiol Immunol. 2003 Aug;18(4):215-9. [PubMed]
10. Salli K, Lehtinen MJ, Tiihonen K, Ouwehand AC. Xylitol’s Health Benefits beyond Dental Health: A Comprehensive Review. Nutrients. 2019 Aug 6;11(8):1813. [PubMed]
11. Desphande A, Jadad AR. The impact of polyol-containing chewing gums on dental caries: a systematic review of original randomized controlled trials and observational studies. J Am Dent Assoc. 2008;139:1602–1614. [PubMed]
12. Söderling E, Pienihäkkinen K. Effects of xylitol and erythritol consumption on mutans streptococci and the oral microbiota: a systematic review. Acta Odontol Scand. 2020;78:599–608. [PubMed]
13. Latifi-Xhemajli B. Effectiveness of xylitol toothpaste in caries prevention: a review article. Georgian Med News. 2024 Sep;(354):32-35. [PubMed]
14. van Loveren C. Sugar alcohols: what is the evidence for caries-preventive and caries-therapeutic effects? Caries Res. 2004 May-Jun;38:286-93. [PubMed]
15. Shyama M, Honkala E, Honkala S, Al-Mutawa SA. Effect of xylitol candies on plaque and gingival indices in physically disabled school pupils. J Clin Dent. 2006;17(1):17-21. [PubMed]
16. Kumar S, Sogi SH, Indushekar KR. Comparative evaluation of the effects of xylitol and sugar-free chewing gums on salivary and dental plaque pH in children. J Indian Soc Pedod Prev Dent 2013 Oct-Dec;31(4):240-4. [PubMed]
17. Jain S, Mathur S. Estimating the effectiveness of lollipops containing xylitol and erythritol on salivary pH in 3-6 years olds: A randomized controlled trial. J Indian Soc Pedod Prev Dent. 2022 Jan-Mar;40(1):19-22. [PubMed]
18. Hegde RJ, Thakkar JB. Comparative evaluation of the effects of casein phosphopeptide amorphous calcium phosphate (CPP ACP) and xylitol containing chewing gum on salivary flow rate, pH and buffering capacity in children: An in vivo study. J Indian Soc Pedod Prev Dent. 2017 Oct-Dec;35(4):332-337. [PubMed]
19. Muralikrishnan K, Asokan S, Priya PR. Effect of different chewing gums on dental plaque pH, salivary pH, and buffering capacity in children: A randomized controlled trial. SRM J Res Dent Sci. 2018 Oct-Dec;9(4):158-63. [Crossref]
20. Chavan S, Lakashminarayan N, Kemparaj U. Effect of Chewing Xylitol Containing and Herbal Chewing Gums on Salivary Mutans Streptococcus Count among School Children. Int J Prev Med. 2015 May 22;6:44. [PubMed]
21. Syed M, Chopra R, Shrivastava V, Sachdev V. Comparative evaluation of 0.2% chlorhexidine mouthwash, xylitol chewing gum, and combination of 0.2% chlorhexidine mouthwash and xylitol chewing gum on salivary Streptococcus mutans and biofilm levels in 8 to 12yearold children. Int J Clin Pediatr Dent. 2016 Oct-Dec;9(4):313-319. [PubMed]
22. Elmokanen MA, Ezzat MA, Ibrahim AH, Shaalan OO. Effect of dissolving xylitol chewable tablets versus xylitol chewing gum on bacterial count and salivary pH in geriatric bedridden patients: A randomized clinical trial. J Int Oral Health. 2022 Jan-Feb;14(1):1725. [Crossref]
23. Mitrakul K, Srisatjaluk R, Vongsawan K, Teerawongpairoj C, Choongphong N, Panich T, et al. Effects of shortterm use of xylitol chewing gum and moltitol oral spray on salivary Streptococcus mutans and oral plaque. Southeast Asian J Trop Med Public Health. 2017 Mar;48(2):485-93. [PubMed]
24. Bogovska-Gigova R, Hristov K, Gateva N, Pencheva-El Tibi I. Evaluation of pH and Acidity in Xylitol Lollipops, Propolis Mouthwash, and Probiotic Lozenges: An in Vitro Study. Int J Sci Res (IJSR). 2024 May;13(5):1791-1795. [Crossref]
Received: 06 December 2024
Published online: 07 April 2025