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Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2025, vol. 31, issue3
Subject Area: Medicine
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DOI: 10.5272/jimab.2025313.6400
Published online: 18 August 2025
Case report
J of IMAB. 2025 Jul-Sep;31(3):6400-6403
UNPREDICTABLE MANIFESTATION OF MORGANELLA MORGANII CHORIOAMNIONITIS AND NEONATAL DEMISE - А CASE REPORT
Katia Telbiyska1, 2
, Mariya Angelova2,
1) Selena University Specialized Hospital for Active Treatment in Obstetrics and Gynecology, Plovdiv, Bulgaria.
2) Department of Obstetrics and Gynecology, Medical Faculty, Trakia University, Stara Zagora, Bulgaria.
ABSTRACT:
Morganella morganii, an opportunistic pathogen from the Enterobacteriaceae family, part of normal intestinal flora in humans, demonstrates a variety of virulent factors, as well as high antimicrobial resistance and mortality. In adults, Morganella morganii is associated with hospital-acquired infections, urinary tract infections in long-term catheter use, wound and hepatobiliary infections. It is not detected in normal vaginal flora and is rarely associated with obstetric infections.
Chorioamnionitis is an inflammatory reaction of chorion and amnion resulting from ascending microbial invasion, although primary intrauterine inflammation has also been reported. This case report presents Morganella morganii chorioamnionitis in a 28-year-old woman, delivering by Cesarean section at 26+3 weeks of gestation, without detection of Morganella morganii in the genitourinary tract, so non-ascending pathogenesis was hypothesized. Neonatal demise occurred irrespective of appropriate therapy for bacteremia.
Morganella morganii chorioamnionitis suggests vertical transmission. In the case presented here, the only risk factor - short-term catheterization, may have been responsible for Morganella morganii chorioamnionitis resulting from a possible genitourinary colonization with low bacterial load, leading to early-onset sepsis andneonatal demise. This clinically verifies the significant virulence of Morganella morganii, with its obstetric and neonatal complications unpredictable.
Keywords: Morganella morganii, chorioamnionitis, complications, neonatal demise,
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Please cite this article as: Telbiyska K, Angelova M. Unpredictable Manifestation of Morganella morganii Chorioamnionitis and Neonatal Demise - a Case Report. J of IMAB. 2025 Jul-Sep;31(3):6400-6403. [Crossref - 10.5272/jimab.2025313.6400]
Correspondence to: Katia Telbiyska, Selena University Specialized Hospital for Active Treatment in Obstetrics and Gynecology, Plovdiv; 80, Peshtersko shosse Str., Plovdiv, Bulgaria; E-mail: dr_k.telbiyska@mail.bg
REFERENCES:
1. Dessie SA, Dobariya V, Singh D, He P. A Case of Morganella morganii-induced Fetal Demise. Cureus. 2020 Mar 3;12(3):e7169. [PubMed]
2. Silva LC, Sanches MS, Guidone GHM, Montini VH, de Oliva BHD, do Nascimento AB, et al. Clonal relationship, virulence genes, and antimicrobial resistance of Morganella morganii isolated from community-acquired infections and hospitalized patients: a neglected opportunistic pathogen. Int Microbiol. 2024 Apr;27(2):411-422. [PubMed]
3. Li H, Chen Z, Ning Q, Zong F, Wang H. Isolation and Identification of Morganella morganii from Rhesus Monkey (Macaca mulatta) in China. Vet Sci. 2024 May 16;11(5):223. [PubMed]
4. Petruzziello L, Scudo M, Logoteta A, Galli V, Mondo A, Di Pinto A, et al. Chorioamnionitis and Sepsis in Pregnant Woman with Vaginal Prolapse of Intact Amniotic Membranes; Maternal and Fetal Outcome: A Case Report. Gynecol Obstet Case Rep. 2020; 6(4):27. [Internet]
5. Carmona F, Fábregues F, Alvarez R, Vila J, Cararach V. A rare case of chorioamnionitis by Morganella morganii complicated by septicemia and adult respiratory distress syndrome. Eur J Obstet Gynecol Reprod Biol. 1992 Jun 16;45(1):67-70. [PubMed]
6. Gameiro I, Botelho T, Martins AI, Henriques R, Lapa P. Morganella morganii: A Rare Cause of Early-Onset Neonatal Sepsis. Cureus. 2023 Sep 20;15(9): e45600. [PubMed ]
7. Alsaadi A, Alghamdi AA, Akkielah L, Alanazi M, Alghamdi S, Abanamy H, et al. Epidemiology and clinical characteristics of Morganella morganii infections: A multicenter retrospective study. J Infect Public Health. 2024 Mar;17(3):430-434. [PubMed]
8. Pineda JCA, Casañas AMH, Hoyos JJS, Caipe NCR, Rua DMP. Chorioamnionitis Caused by Morganella Morganii in a Patient With Recent Infection by Sars-cov-2: A Case Report. Research Square. 20 Aug 2023. [Intenet]
9. Pham B, Denslow A, Mikhael M, Lim J. A Case of an Extremely Low Birth Weight Infant with Morganella morganii Bacteremia and Peritonitis. AJP Rep. 2021 Apr;11(2): e113-e118. [PubMed]
10. Erlanger D, Assous MV, Wiener-Well Y, Yinnon AM, Ben-Chetrit E. Clinical manifestations, risk factors and prognosis of patients with Morganella morganii sepsis. J Microbiol Immunol Infect. 2019 Jun;52(3):443-448. [PubMed]
11. Zaric RZ, Jankovic S, Zaric M, Milosavljevic M, Stojadinovic M, Pejcic A. Antimicrobial treatment of Morganella morganii invasive infections: Systematic review. Indian J Med Microbiol. 2021 Oct-Dec;39(4):404-412. [PubMed]
12. Chang CN, Chen SJ, Wang CC, Lo WT. Successful Treatment of Early-Onset Morganella morganii Sepsis in an Extremely Low Birth Weight Infant. J Med Sci. 2022 Jul-Aug;42(4):194-196. [Crossref]
13. De Sousa R, Ecoffey M, Gervaix A. Unexplained severe periventricular leukomalacia in an otherwise healthy premature infant: Role of maternal Morganella morganii chorioamnionitis? BMJ Pub Group Arch Dis Child. 2008; 93(Suppl 2):ps251. [Internet]
14. Johnson JR, Feingold M. Case of chorioamnionitis in an immunocompetent woman caused by Morganella morganii. J Matern Fetal Med. 1998 Jan-Feb;7(1):13-4. [PubMed]
15. Laupland KB, Paterson DL, Edwards F, Stewart AG, Harris PNA. Morganella morganii, an Emerging Cause of Bloodstream Infections. Microbiol Spectr. 2022 Jun 29;10(3): e0056922. [PubMed ]
16. Karlbom O, Sunnerhagen T, Ljungquist O. Morganella morganii bloodstream infection affects the elderly in close contact with health care. IJID Reg. 2024 Oct 24; 13:100480. [PubMed]
17. Lin TY, Chan MC, Yang YS, Lee Y, Yeh KM, Lin JC, et al. Clinical manifestations and prognostic factors of Morganella morganii bacteremia. Eur J Clin Microbiol Infect Dis. 2015 Feb;34(2):231-6. [PubMed ]
18. Lee IK, Liu JW. Clinical characteristics and risk factors for mortality in Morganella morganii bacteremia. J Microbiol Immunol Infect. 2006 Aug;39(4):328-34. [PubMed]
19. Liu H, Zhu J, Hu Q, Rao X. Morganella morganii, a non-negligent opportunistic pathogen. Int J Infect Dis. 2016 Sep;50:10-7. [PubMed]
20. Bandy A. Ringing bells: Morganella morganii fights for recognition. Public Health. 2020 May;182:45-50. [PubMed]
Received: 29 April 2025
Published online: 18 August 2025