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Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2025, vol. 31, issue3
Subject Area: Medicine
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DOI: 10.5272/jimab.2025313.6447
Published online: 10 September 2025
Case report
J of IMAB. 2025 Jul-Sep;31(3):6447-6451
THYROID METASTASES FROM OVARIAN SEROUS CARCINOMA: A RARE CASE REPORT
Doroteya Malinova1, 2
, Radina Dimitrova3, 4, Mira Siderova3, 4, Borislav Chaushev5, 6,
1) Department of General and Clinical Pathology, Forensic Medicine and Deontology, Faculty of Medicine, Medical University - Varna, Bulgaria.
2) Clinic of General and Clinical Pathology, University Hospital St. Marina, Varna, Bulgaria.
3) Second Department of Internal Diseases, Faculty of Medicine, Medical University - Varna, Bulgaria.
4) Clinic of Endocrinology and Metabolic Diseases, University Hospital St. Marina, Varna, Bulgaria.
5) Department of Periodontology and Dental Implantology, Faculty of Dental Medicine, Medical University - Varna, Bulgaria.
6) Clinic of Nuclear Medicine, University Hospital St. Marina, Varna, Bulgaria.
ABSTRACT:
Introduction: We present a female patient with ovarian serous papillary carcinoma with thyroid gland metastases and metastases to cervical lymph nodes. Ovarian serous papillary carcinoma accounts for the majority of ovarian carcinoma diagnoses and related deaths. It is characterized by an advanced disease at presentation in about 80% of cases. It is associated with elevated serum CA-125 levels. Metastases of ovarian carcinoma to the thyroid gland are very rare, with only four cases reported in the literature.
Case report: A 73-year-old woman presented to “St Marina” University Hospital in Varna, Bulgaria. She had been experiencing dyspnoea and a change in her voice over the past month. She was diagnosed with ovarian carcinoma five years ago. The clinical exam showed an enlarged thyroid gland and cervical lymph nodes enlargement. The imaging tests revealed a tumor mass in the thyroid gland and cervical lymph nodes, as well as generalized lymphadenopathy. Fine-needle aspiration (FNA) biopsy was performed, and the findings in the thyroid gland and in one of the lymph nodes were assessed as metastatic lesions from ovarian carcinoma. The cytology was negative for primary thyroid tumor, as well as thyroglobulin was negative in the lymph node wash out.
Conclusions: Metastases to the thyroid gland are very rare and should be considered when evaluating a patient with advanced ovarian cancer. FNA remains a sensitive and specific method for detecting malignant lesions in the thyroid gland.
Keywords: ovarian carcinoma, metastases, thyroid gland, FNA, CA-125,
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Please cite this article as: Malinova D, Dimitrova R, Siderova M, Chaushev B. Thyroid metastases from ovarian serous carcinoma: a rare case report. J of IMAB. 2025 Jul-Sep;31(3):6447-6451. [Crossref - 10.5272/jimab.2025313.6447]
Correspondence to: Doroteya Malinova, MD, Department of General and Clinical Pathology, Forensic Medicine and Deontology, Faculty of Medicine, Medical University – Varna; Clinic of General and Clinical Pathology, University Hospital St. Marina, Varna; 1, Hr. Smirnenski Blvd., 9010 Varna, Bulgaria; E-mail: dmalinova@gmail.com
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Received: 04 March 2025
Published online: 10 Septtember 2025