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Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2025, vol. 31, issue3
Subject Area: Medicine
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DOI: 10.5272/jimab.2025313.6477
Published online: 25 September 2025
Review article
J of IMAB. 2025 Jul-Sep;31(3):6477-6483
BIOMEDICAL CHARACTERISTICS AND EVALUATION OF CHITOSAN, BIOACTIVE GLASS AND LAPONITE®/BMP-2 AS SURFACE IMPLANT COATINGS: A SYSTEMATIC REVIEW
Nikoleta Ivanova1
, Stoyan Ivanov2, Tsanka Dikova3,
1) Department of Biology, Faculty of Pharmacy, Medical University of Varna, Bulgaria.
2) Department of Orthopedics and Traumatology, Faculty of Medicine, Medical University of Varna, Bulgaria.
3) Department of Dental Materials and Prosthetic Dental Medicine, Faculty of Dental Medicine, Medical University of Varna, Bulgaria.
ABSTRACT:
Purpose: The surface coatings of implants primarily used in orthopedics and dentistry are developed to improve osseointegration with the body's tissues and ensure durability and functionality. In surgical practice, there is large diversity of options for grafting materials to manage bone loss, promote osteoinduction and accelerate implant integration and survival. The aim of the present study is to analyze and evaluate the biomedical characteristics of Chitosan, Bioactive glass and Laponite®/BMP-2 as potential substances for surface coatings of implants.
Material/Methods: A search for scientific studies was conducted in the electronic databases: Google Scholar and PubMed for a period of ten years (2014-2024)ith keywords: Biomedical characteristics, Chitosan, Bioactive glass, Laponite (BMP-2), implant surface coatings.
Results: Results demonstrated that chitosan used as a coating for implant materials promotes osteointegration both in vitro and in vivo. Coating the implant with bioactive glasses leads to improved stability as well as the connection between the coating and the implant. The combination of Laponite®'s biocompatibility and the osteoinductive properties of BMP-2 as surface implant coating can enhance the healing of bone defects and accelerate osteointegration.
Conclusion: This review highlights the main characteristics of commonly used bone substitutes and provides guidance on their clinical use in orthopedic and traumatology practice and periodontal treatment in terms of improving their durability.
Keywords: Biomedical characteristics, Chitosan, Bioactive glass, Laponite (BMP-2), implant surface coatings,
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Please cite this article as: Ivanova N, Ivanov S, Dikova T. Biomedical characteristics and evaluation of Chitosan, Bioactive glass and Laponite®/BMP-2 as surface implant coatings: A Systematic review. J of IMAB. 2025 Jul-Sep;31(3):6477-6483. [Crossref - 10.5272/jimab.2025313.6477]
Correspondence to: Nikoleta Ivanova, Department of Biology, Faculty of Pharmacy, Medical University of Varna; 84, Tsar Osvoboditel Str., Varna, 9000, Bulgaria; E-mail: nikoleta.ivanova@mu-varna.bg
REFERENCES:
1. Fernandez de Grado G, Keller L, Idoux-Gillet Y, Wagner Q, Musset AM, Benkirane-Jessel N, et al. Bone substitutes: a review of their characteristics, clinical use, and perspectives for large bone defects management. J Tissue Eng. 2018 Jun 4;9:2041731418776819. [PubMed]
2.Ozkan A, Çakır DA, Tezel H, Sanajou S, Yirun A, Baydar T, et al. Dental Implants and Implant Coatings: A Focus on Their Toxicity and Safety. J Environ Pathol Toxicol Oncol. 2023;42(2):31-48. [PubMed]
3. Peev S, Yotsova R, Parushev I. Histomorphometric Analysis of Osseointegrated Intraosseous Dental Implants Using Undecalcified Specimens: A Scoping Review. Biomimetics (Basel). 2024 Nov 3;9(11):672. [PubMed]
4. Hudieb M, AlKhader M, Mortaja S, Abusamak M, Wakabayashi N, Kasugai S. Impact of Bone Augmentation of Facial Bone Defect around Osseointegrated Implant: A Three Dimensional Finite Element Analysis. Dent J (Basel). 2021 Oct 3;9(10):114. [PubMed]
5. Shaikh MQ, Nath SD, Akilan AA, Khanjar S, Balla VK, Grant GT, et al. Investigation of Patient-Specific Maxillofacial Implant Prototype Development by Metal Fused Filament Fabrication (MF3) of Ti-6Al-4V. Dent J (Basel). 2021 Sep 23;9(10):109. [PubMed]
6. El-Banna A, Bissa MW, Khurshid Z, Zohaib S, Asiri FYI, Zafar MS. Surface modification techniques of dental implants. Dental Implants. 2020; Chapter 4, pp. 49-68. [Crossref]
7. Jaquiéry C, Ilgenstein B, Jungo M, Rüeger K, Chenaux S, Papadimitropoulos A, et al. Clinical and radiological outcome of titanium implants in clinical practice: A 5 year, prospective, multicenter case series. Dent J. 2014; 2(4):106-117. [Crossref]
8. Alghamdi HS, Cuijpers VM, Wolke JG, van den Beucken JJ, Jansen JA. Calcium-phosphate-coated oral implants promote osseointegration in osteoporosis. J Dent Res. 2013 Nov;92(11):982-8. [PubMed]
9. Stadlinger B, Korn P, Tödtmann N, Eckelt U, Range U, Bürki A. Osseointegration of biochemically modified implants in an osteoporosis rodent model. Eur Cell Mater. 2013 Jul 8;25:326-40; discussion 339-40. [PubMed]
10. López-Valverde N, Aragoneses J, López-Valverde A, Rodríguez C, Macedo de Sousa B, Aragoneses JM. Role of chitosan in titanium coatings. trends and new generations of coatings. Front Bioeng Biotechnol. 2022 Jul 22;10:907589. [PubMed]
11. Khan A, Wang B, Ni Y. Chitosan-Nanocellulose Composites for Regenerative Medicine Applications. Curr Med Chem. 2020;27(28):4584-4592. [PubMed]
12. Aranaz I, Mengíbar M, Harris R, Paños I, Miralles B, Acosta N, et al. Functional Characterization of Chitin and Chitosan. Current Chemical Biology, 2009, 3 (2): 203-230.
13. Sukul M, Sahariah P, Lauzon HL, Borges J, Másson M, Mano JF, et al. In vitro biological response of human osteoblasts in 3D chitosan sponges with controlled degree of deacetylation and molecular weight. Carbohydr Polym. 2021 Feb 15;254:117434. [PubMed]
14. Polo-Corrales L, Latorre-Esteves M, Ramirez-Vick JE. Scaffold design for bone regeneration. J Nanosci Nanotechnol. 2014 Jan;14(1):15-56. [PubMed]
15. Teixeira-Santos R, Lima M, Gomes LC, Mergulhão FJ. Antimicrobial coatings based on chitosan to prevent implant-associated infections: A systematic review. iScience. 2021 Nov 22;24(12):103480. [PubMed]
16. Desai N, Rana D, Salave S, Gupta R, Patel P, Karunakaran B, et al. Chitosan: A Potential Biopolymer in Drug Delivery and Biomedical Applications. Pharmaceutics. 2023 Apr 21;15(4):1313. [PubMed]
17. Oliveira WF, Albuquerque BP, Rodrigues EN, Silva MP, Kennedy JF, Correia MS, et al. Pharmaceutical applications of chitosan on medical implants: A viable alternative for construction of new biomaterials? Carbohydr Polym Technol Appl. 2024 Jun;7:100407. [Crossref]
18. Oliver JN, Su Y, Lu X, Kuo PH, Du J, Zhu D. Bioactive glass coatings on metallic implants for biomedical applications. Bioact Mater. 2019 Oct 5;4:261-270. [PubMed]
19. Chand P, Malik M, Prasad T. Bioactive Glass for Applications in Implants: A Review. SchemistrySelect. 2024, 9, 29.
20. Sola D, Bellucci V, Cannillo A, Cattini A. Bioactive glass coatings: a review Surf. Eng. 27, 2011, 560-572.
21. Manam S., Harun W, Awang N, Bin S., Kurniawan T, Ismail M, et al. Study of corrosion in biocompatible metals for implants: a review. J. Alloys Compd. 2017, 701, 698–715.
22. Liang J, Lu X, Zheng X, Li YR, Geng X, Sun K, et. al. Modification of titanium orthopedic implants with bioactive glass: a systematic review of in vivo and in vitro studies. Front Bioeng Biotechnol. 2023 Nov 15;11:1269223. [PubMed]
23. Kargozar S, Baino F, Hamzehlou S, Hill RG, Mozafari M. Bioactive Glasses: Sprouting Angiogenesis in Tissue Engineering. Trends Biotechnol. 2018 Apr;36(4):430-444. [PubMed]
24. Yanovska A, Kuznetsov V, Stanislavov A, Danilchenko S, Sukhodub L. Synthesis and characterization of hydroxyapatite-based coatings for medical implants obtained on chemically modified Ti6Al4V substrates. Surf. Coatings Technol. 2011 Sep 25;205(23-24):5324–5329. [Crossref]
25. Howard MT, Wang S, Berger AG, Martin JR, Jalili-Firoozinezhad S, Padera RF, et al. Sustained release of BMP-2 using self-assembled layer-by-layer film-coated implants enhances bone regeneration over burst release. Biomaterials. 2022 Sep;288:121721. [PubMed]
26. King WJ, Krebsbach PH. Growth factor delivery: how surface interactions modulate release in vitro and in vivo. Adv Drug Deliv Rev. 2012 Sep;64(12):1239-56. [PubMed]
27. Cheng CH, Lai YH, Chen YW, Yao CH, Chen KY. Immobilization of bone morphogenetic protein-2 to gelatin/avidin-modified hydroxyapatite composite scaffolds for bone regeneration. J Biomater Appl. 2019 Apr;33(9):1147-1156. [PubMed]
28. Erezuma I, Eufrasio-da-Silva T, Golafshan N, Deo K, Mishra YK, Castilho M, et al. Nanoclay Reinforced Biomaterials for Mending Musculoskeletal Tissue Disorders. Adv Healthc Mater. 2021 Aug;10(16):e2100217. [PubMed]
29. Marshall K, McLaren J, Wojciechowski J, Callens S, Echalier S, Kanczler J, et al. Bioactive coatings on 3D printed scaffolds for bone regeneration: Use of Laponite™ to deliver BMP-2 for bone tissue engineering – progression through in vitro, chorioallantoic membrane assay and murine subcutaneous model validation. Biomater Adv. 2023 Nov;164:213959. [PubMed]
30. Black C, Gibbs D, McEwan J, Kanczler J, Fernández MP, Tozzi G, et al. Comparison of bone formation mediated by bone morphogenetic protein delivered by nanoclay gels with clinical techniques (autograft and InductOs®) in an ovine bone model. J Tissue Eng. 2022 Sep 16;13:20417314221113746. [PubMed]
31. Zerankeshi M, Mofakhami S, Salahinejad E. 3D porous HA/TCP composite scaffolds for bone tissue engineering. Ceramics International. 2022 48, 22647-22633.
32. Erezuma I, Eufrasio-da-Silva T, Golafshan N, Deo K, Mishra YK, Castilho M, et al. Nanoclay Reinforced Biomaterials for Mending Musculoskeletal Tissue Disorders. Adv Healthc Mater. 2021 Aug;10(16):e2100217. [PubMed]
33. Liu Z, Tang Q, Liu RT, Yu MZ, Peng H, Zhang CQ, et al. Laponite intercalated biomimetic multilayer coating prevents glucocorticoids induced orthopedic implant failure. Bioact Mater. 2022 Sep 26;22:60-73. [PubMed]
34. Zhang X, Xu Y, Zhang X, Wu H, Shen J, Chen R, et al. Progress on the layer-by-layer assembly of multilayered polymer composites: strategy, structural control and applications. Prog Polym Sci. 2019 Feb;89:76-107. [Crossref]
35. Sikkema R, Baker K, Zhitomirsky I. Electrophoretic deposition of polymers and proteins for biomedical applications. Adv Colloid Interface Sci. 2020 Oct;284:102272. [PubMed]
36. Drevet R, Fauré J, Benhayoune H, Electrophoretic Deposition of Bioactive Glass Coatings for Bone Implant Applications: A Review. Coatings. 2024; 14(9):1084. [Crossref]
37. Skallevold HE, Rokaya D, Khurshid Z, Zafar MS. Bioactive Glass Applications in Dentistry. Int J Mol Sci. 2019 Nov 27;20(23):5960. [PubMed]
38. Jafari N, Habashi MS, Hashemi A, Shirazi R, Tanideh N, Tamadon A. Application of bioactive glasses in various dental fields. Biomater Res. 2022 Jul 6;26(1):31. [PubMed]
39. Hammami I, Gavinho SR, Pádua AS, Sá-Nogueira I, Silva JC, Borges JP, et al. Bioactive Glass Modified with Zirconium Incorporation for Dental Implant Applications: Fabrication, Structural, Electrical, and Biological Analysis. Int J Mol Sci. 2023 Jun 24;24(13):10571. [PubMed]
40. Lopez S, Saiz E, Fujini S, Oku T, Suganuma K, Tomsia A. Bioactive glass coatings for orthopedic metallic implants. J Eur Ceram Soc. 2003; 23(15):2921-2930. [Crossref]
Received: 21 January 2025
Published online: 25 Septtember 2025