 |
Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2025, vol. 31, issue4
Subject Area: Medicine
-
DOI: 10.5272/jimab.2025314.6532
Published online: 08 October 2025
Case report
J of IMAB. 2025 Oct-Dec;31(4):6532-6536
BEDNAR’S TUMOR – A RARE VARIANT OF DERMATOFIBROSARCOMA PROTUBERANS
Stoyan Pavlov
, Yavor Penev,
Department of Infectious Diseases, Parasitology, and Dermatovenerology, Medical University of Varna, Bulgaria.
ABSTRACT:
Bednar’s tumor is a rare pigmented variant of dermatofibrosarcoma protuberans (DFSP)—a cutaneous sarcoma of low to intermediate malignancy, characterized by a tendency for local recurrence. Histologically, it is defined by the presence of spindle-shaped cells arranged in a storiform pattern and melanin-containing dendritic cells. Clinically, the lesions often resemble melanoma or other pigmented dermal tumors.
We present the case of a 66-year-old male with a long-standing, asymptomatic pigmented lesion in the right subclavicular region. Histopathological examination confirmed the diagnosis of Bednar’s tumor based on its characteristic morphology and immunohistochemical profile: diffuse CD34 expression in spindle cells and S-100 positivity in melanin-laden components. Radical surgical excision with a 2 cm margin was performed. Follow-up over a two-year period revealed no evidence of recurrence or metastasis, as confirmed by PET/CT.
This case highlights the importance of early diagnosis, immunohistochemical distinction from melanoma, and the need for a multidisciplinary approach in managing rare cutaneous sarcomas with atypical presentation.
Keywords: dermatofibrosarcoma protuberans, Bednar’s tumor, pigmented tumor, Immunohistochemistry, PET scan,
- Download FULL TEXT /PDF 1879 KB/
Please cite this article as: Pavlov S, Penev Y. Bednar’s Tumor – A Rare Variant of Dermatofibrosarcoma Protuberans. J of IMAB. 2025 Oct-Dec;31(4):6532-6536. [Crossref - 10.5272/jimab.2025314.6532]
Correspondence to: Stoyan Pavlov, Department of Infectious Diseases, Parasitology, and Dermatovenereology, Medical University of Varna; 55, Marin Drinov Str., Varma 9002, Bulgaria; E-mail: stoyanpavlov@abv.bg
REFERENCES:
1. Jozwik M, Bednarczuk K, Osierda Z. Dermatofibrosarcoma Protuberans: An Updated Review of the Literature. Cancers (Basel). 2024 Sep 11;16(18):3124. [PubMed]
2. Rouhani P, Fletcher CDM, Devesa SS, Toro JR. Cutaneous soft tissue sarcoma incidence patterns in the U.S. Cancer. 2008 Aug 1;113(3):616–27. [PubMed]
3. Dupree WB, Langloss JM, Weiss SW. Pigmented dermatofibrosarcoma protuberans (Bednar tumor). A pathologic, ultrastructural, and immunohistochemical study. Am J Surg Pathol. 1985 Sep;9(9):630–9. [PubMed]
4. Agarwal A, Rana C. Pigmented dermatofibrosarcoma (Bednar tumour) of scalp. BMJ Case Rep. 2023 Sep 27;16(9):e254473. [PubMed]
5. Llombart B, Serra-Guillén C, Monteagudo C, Lуpez Guerrero JA, Sanmartнn O. Dermatofibrosarcoma protuberans: a comprehensive review and update on diagnosis and management. Semin Diagn Pathol. 2013 Feb;30(1):13-28. [PubMed]
6. Kim H. Dermatofibrosarcoma protuberans in the breast: Case report. Int J Surg Case Rep. 2021 Apr;81:105773. [PubMed]
7. Hussain SK, Sundquist J, Hemminki K. Incidence Trends of Squamous Cell and Rare Skin Cancers. J Invest Dermatol. 2010 May;130(5):1323–8. [PubMed]
8. Monnier D, Vidal C, Martin L, Danzon A, Pelletier F, Puzenat E, et al. Dermatofibrosarcoma protuberans: a population-based cancer registry descriptive study of 66 consecutive cases diagnosed between 1982 and 2002. J Eur Acad Dermatol Venereol. 2006 Nov;20(10):1237-42. [PubMed]
9. Akram J, Wooler G, Lock-Andersen J. Dermatofibrosarcoma protuberans: clinical series and incidence in Denmark. J Plast Surg Hand Surg. 2014 Feb;48(1):67–73. [PubMed]
10. Mallett KE, Almubarak S, Claxton RM, Larkin J, Blay JY, Coindre JM, et al. Risk Factors for Fibrosarcomatous Transformation in DFSP. Anticancer Res. 2022 Jan;42(1):105–8. [PubMed]
11. Beaziz J, Battistella M, Delyon J, Debarbieux S, Schmitz A, Ghnassia JP, et al. Neoadjuvant TKI in DFSP. Cancers (Basel). 2021 May 6;13(9):2224. [PubMed]
12. Zhang Y, Zhu L, Liu Y, Liu H, Chen J, Wang Y, et al. Clinical and histopathological characteristics of atrophic pigmented dermatofibrosarcoma protuberans: a retrospective study of 14 cases. Heliyon. 2024 Oct 11;10(22):e39271. [PubMed]
13. Cekić S, Jović A, Popović D, Jovanović M, Stanojević D. Bednar Tumor – a Case Report. Serbian J Dermatol Venereol. 2020 Oct 23;12(2):59–62. [Crossref]
14. Chen Y, Jiang G. Excision margins and outcomes in DFSP: meta-analysis. Dermatol Ther. 2021 Jul;34(4):14954. [PubMed]
15. Sei JF, Tchakerian A, Zimmermann U, Clerici T, Chaussade V, Franc B, et al. Treatment of dermatofibroma protuberans with fixed Mohs’ micrographic surgery]. [in French] Ann Dermatol Venereol. 2004 Feb;131(2):158-60. [PubMed]
16. Menon G, Brooks J. Ramsey ML. Dermatofibrosarcoma Protuberans. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan. 2024 Apr 18. [PubMed]
17. Mancari R, Cioffi R, Magazzino F, Attademo L, Sant’angelo M, Taccagni G, et al. Dermatofibrosarcoma Protuberans of the Vulva: A Review of the MITO Rare Cancer Group. Cancers (Basel). 2024 Jan 3;16(1):222. [PubMed]
18. Apalla Z, Liopyris K, Kyrmanidou E, Fotiadou C, Sgouros D, Patsatsi A, et al. Clinical and dermoscopic characteristics of cutaneous sarcomas: A literature review. Diagnostics (Basel). 2023 May 22;13(10):1822. [PubMed]
19. Тariq MU, Din NU, Abdul-Ghafar J, Park YK. The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior. Diagn Pathol. 2021 Apr 20;16(1):32. [PubMed]
Received: 09 July 2025
Published online: 08 October 2025