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Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2025, vol. 31, issue4
Subject Area: Medicine
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DOI: 10.5272/jimab.2025314.6626
Published online: 25 November 2025
Review article
J of IMAB. 2025 Oct-Dec;31(4):6619-6625
A COMPLEX BUT BENEFICIAL RELATIONSHIP BETWEEN PLATINUM COMPOUNDS AND ORGANIC DRUGS – A MINI-REVIEW ON THE ANTIMICROBIAL PERSPECTIVE
Nedelina Kostadinova1
, Valentina Belcheva2, Pavlina Teneva1, Dobrilina Yarkova3, Krum Kafedjiiski2,
1) Department of Health Care, Medical College, Trakia University - Stara Zagora, Bulgaria.
2) Department of Pharmaceutical Sciences, Medical College, Trakia University - Stara Zagora, Bulgaria.
3) Faculty of Medicine, Trakia University - Stara Zagora, Bulgaria.
ABSTRACT:
Nowadays, a high number of diseases are connected to bacterial or viral infections. The treatment of the patients is getting more and more difficult, the reason being the smart strategies that microbes facilitate to escape the antibiotics' influence.
Purpose: This review presents a literature investigation conducted in 2025 regarding platinum as a source for developing metalloantibiotics and antibacterial agents.
Material/Methods: A study on scientific publications was done in different databases, using the necessary search terms in the scientific literature.
Results and discussion: We focus on the various mechanisms that could be used with the participation of platinum complexes and nanoparticles in order to affect the development of bacterial biofilms and the spread of infections. We discuss the beneficial combinations of platinum compounds with other drugs or metals that reveal a synergistic effect in the fight against microbial growth.
The conclusion is that the use of platinum complexes and antimicrobial drugs is getting a deeper perspective for developing new combination treatments as well as new metallodrugs that are potent and could have more effective application against antimicrobial resistance and for the treatment of various infections.
Keywords: platinum complexes, metallodrugs, antimicrobial activity, antimicrobial resistance,
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Please cite this article as: Kostadinova N, Belcheva V, Teneva P, Yarkova D, Kafedjiiski K. A complex but beneficial relationship between platinum compounds and organic drugs – a mini-review on the antimicrobial perspective. J of IMAB. 2025 Oct-Dec;31(4):6626-6630. [Crossref - 10.5272/jimab.2025314.6626]
Correspondence to: Assoc. Prof. Nedelina Kostadinova, Ph.D., Department of Health care, Medical college at Trakia University-Stara Zagora; 9, Armeiska Str., Stara Zagora, Bulgaria; E-mail: nedelina.kostadinova@trakia-uni.bg
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Received: 28 October 2025
Published online: 25 November 2025