back to 2007, vol. 13, b. 1
Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2007, vol. 13, book 1
Subject Collection: Medicine
Page: 27-30
DOI: 10.5272/jimab.2007131.25
Online date: September 10, 2007

J of IMAB 2007; 13(1):27-30
Galya I. Gancheva, Chrisima Tzvetanova, Penka Ilieva, Iskra Simova
Department of Infectious Diseases, Epidemiology, Parasitology and Tropical Medicine; Medical University, Pleven, Bulgaria

Retrospectively have been studied clinical signs and routine laboratory investigations of patients with leptospirosis (n 1=94) and acute viral hepatitis (AVH) (n 2=1705). The comparison of results in two groups have revealed significant differences in the frequency of acute onset in leptospirosis and AVH with fever (respectively in 100% and 58,01%; p<0,005); pains in calf muscles (in leptospirosis in 85,11%, in AVH have not been observed); headache (resp. in 68,08 and 18,96%; p<0,005); anorexia (resp. in 64,89 and 87,36%; p<0,005); lumbar pains (in leptospirosis in 40,43%, in AVH have not been observed); clay colored stool (resp. in 6,38 and 93,60%; p<0,005); heaviness in abdomen (resp. in 3,19 and 84,38%; p<0,005); hepatic tenderness (resp. in 41,49 and 76,63%; p<0,005); conjunctival injection only in leptospirosis (86,17%). Routine laboratory investigations have been demonstrated anemia, leucocytosis, granulocytosis, increased erythro­cytes sedi­men­tation rate (ESR) and thrombocytopenia significantly often in leptospirosis than in AVH (p<0,005). The comparison of results of liver biochemical investi­gations have been established increased serum bilirubin in lepto­spirosis and AVH (resp. in 75,00 and 93,60%; p<0,05); mildly increased aminotransferases activities in leptospirosis and extremely increased in AVH (p<0,005); increased creatinkynase in leptospirosis; increased fibrinogen level in leptospirosis (av. 6,74 g/L), normal to decreased in AVH (av. 3,01 g/L) (p<0,005). Nitrogen parameters have been increased in leptospirosis with ARF.

Key words: leptospirosis, acute viral hepatitis, acute renal failure, liver biochemical parameters, creatinkynase, nitrogen parameters.

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Please cite this article as:
Gancheva GI, Tzvetanova Chr, Ilieva P, Simova I. COMPARATIVE STUDY IN LEPTOSPIROSIS AND ACUTE VIRAL HEPATITIS. J of IMAB. 2007; 13(1):27-30. doi: 10.5272/jimab.2007131.25

1. Bounlu K., Insisiengmay S., Vanthanouvong K. Saykham, Widjaja S, Iinuma K, et al. Acute jaundice in Vientiane, Lao People’s Democratic Republic. Clin Infect Dis. 1998 Oct;27(4):717-21. [PubMed] [CrossRef]
2. Christov Chr., Gancheva G., Georgiev N. et al. Comperative studies in leptospirosis and viral hepatitis in Pleven region. Infectology, 1998; (4):23-26. [in Bulgarian]
3. Cunha B.A. Systemic infections affecting the liver. Some cause jaundice, some do not. Postgrad Med. 1988 Oct; 84(5):148-58, 161-3, 166-8. [PubMed]
4. Deepak NA., Patel ND. Differential diagnosis of acute liver failure in India. Ann Hepatol. 2006 Jul-Sep;  5(3):150-6. [PubMed]
5. Johnson WD.Jr., Silva IC, Rocha H. Serum creatine phosphokinase in leptospirosis. JAMA. 1975 Sep 1; 233 (9) :981-2. [PubMed]
6. Kothari V. M., Karnad D. R., Bichile LS. Tropical infections in the ICU. J Assoc Physicians India. 2006 Apr; 54:291-8. [PubMed]
7. Mel’nik GV, Avdeeva MG, Piskunov OV. The importance of myoglobin in the pathogenesis of leptospirosis. Ter Arkh. 1997; 69(4):69-72. [in Russian]. [PubMed]
8. Mel’nik GV, Degtiar’ LD, Zhukova LI. Hepatobiliary alternations in leptospirosis convalescents. Ter Arkh. 2000; 72(2):18-21. [in Russian]. [PubMed
9. Montoliu J, Coca A, Martinez-Orozco F, Darnell A, Subías R, Revert L. Acute renal failure complicating viral hepatitis in the absence of severe hepatic insufficiency. Am J Nephrol. 1985; 5(5):372-4. [PubMed]
10. Pupkevich-Diamant Ia S. Certain indicators of enzymograms and their diagnostic value in leptospirosis and viral jaundice. Lab Delo. 1976; (5):289-93. [in Russian]. [PubMed]
11. Pupkevich-Diamant Ia. S., Nisnevich EB. Activity of dehydro­ge­na­ses and their isoenzymes in the blood of patients with leptospirosis and viral hepatitis. Lab Delo. 1984; (10):589-93. [in Russian]. [PubMed]
12. Pupkevich-Diamant Ia. S., Nisnevich EB. Blood enzyme and isoenzyme spectra in leptospiral and viral jaundice. Klin Med (Mosk). 1986 Apr; 64(4):85-91. [in Russian]. [PubMed]
13. Shuvalova EP, Rakhmanova AG, Antonova TV. Characteristics of the pathogenesis of the hemorrhagic syndrome in viral hepatitis and the icteric form of leptospirosis. Klin Med (Mosk). 1984 May; 62(5):93-6. [in Russian]. [PubMed]
14. Ugriumov BL, Vovk AD, Alekseeva NV, Iurkovskaia NB, Reznik MM. Differential diagnosis of Vasiliev-Weil disease. Vrach Delo. 1976 Sep; (9):137-42. [in Russian]. [PubMed]
15. Ugriumov BL, Vovk AD., Tat’ianko NV, Iurkovskaia N. B., Kudriavtseva N. G. Analysis of diagnostic errors in leptospirosis. Vrach Delo. 1980 Nov; (11):112-6. [in Russian]. [PubMed]

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