Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2008, vol. 14, book 1
Subject Collection: Medicine
Page: 72-75
DOI: 10.5272/jimab.14-1-2010.72
Online date: October 07, 2008

J of IMAB 2008; 14(1)72-75
SNEDDON’S SYNDROME
Valentin Valtchev¹, Virginia Simeonova², Dimitar Gospodinov¹, Ivelina Yordanova¹, Valentina Dimitrova¹, Verka Pavlova¹, Emiliana Konova⁴, Savelina Popovska³, Boyko Stamenov²
1) Department of Dermatology and Venereology, Medical University – Pleven, Bulgaria
2) Department of Neurology, Medical University – Pleven, Bulgaria
3) Department of General and Clinical Pathology, Medical University – Pleven, Bulgaria
4) Department of Immunology, Medical University – Pleven, Bulgaria

ABSTRACT:
Sneddon’s syndrome is usually characterized by the association of an ischemic cerebrovascular disease and a widespread livedo reticularis. The incidence of Sneddon syndrome is 4/1000 000. We present 42-year-old woman with livedo reticularis, recurrence ischaemic cerebrovascular accidents, two repetitive miscarriages and positive anti-2GPi antibodies. Skin biopsy specimens reveal inflammatory changes of small- to medium-sized arteries and subendothelial proliferation and fibrosis. The diagnosis Sneddon syndrome is confirmed by skin biopsy, and MR evidence.
We suggest that anti-2GPi antibodies may be pathophysiologically related to the clinical manifestation observed in some patients with Sneddon syndrome.

Key words: Sneddon syndrome, livedo reticularis, ischemic cerebrovascular disease.

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Please cite this article as:
Valtchev V, Simeonova V, Gospodinov D, Yordanova I, Dimitrova V, Pavlova V, Konova E, Popovska S, Stamenov B. SNEDDON’S SYNDROME. J of IMAB. 2008; 14(1):72-75. DOI: 10.5272/jimab.14-1-2010.72

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