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Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312-773X (Online)
Issue: Volume 15, book 1, 2009
Subject Collection: Medicine
Page: 6 - 8
DOI: 10.5272/jimab.1512009_6
Online date:June 15, 2009
Mechanisms of cell resistance in glioblastoma
multiforme
Victoria Sarafian1,
Ilian Koev2, Dmitrii Staykov3
1 Department of Biology; 2 Department of Neurosurgery, 3 Department of
General and Clinical Pathology; Medical University - Plovdiv, Bulgaria
SUMMARY: Glioblastoma multiforme is the most common
brain tumor in adults. It is characterized by a rapid clinical course
and extremely unfavorable prognosis. The etiology and the molecular pathogenetic
mechanisms are not entirely clear yet. Active proliferation, resistance
to apoptosis and high angiogenicity are basic factors limiting the effect
of standard therapy.
A significant problem is the resistance of glioblastoma cells to apoptosis
induced by most of antitumor drugs and radiotherapy. The functional activity
of several tumor-suppressor genes is inhibited. The antiapoptotic effect
of the normal brain matrix and the altered expression of integrin aVb3
act as main regulators of angiogenesis, invasion and proliferation of
glioblastoma cells.
Therapeutic strategies are based on cellular and molecular mechanisms
leading to: activation of apoptosis, inhibition of growth factors and
receptors, and blocking of angiogenesis. Crucial moment in modern therapy
is the activation of autophagy. Its effectiveness depends on the expression
level of genes mTOR and MTMG. The most promising approach is the complex
one combining surgery, radiotherapy and targeted molecular therapy directed
simultaneously to different cellular pathogenetic mechanisms.
Key words: glioblastoma, apoptosis, autophagy, resistance.
Page: 6-8; FULL TEXT PDF (151 KB)