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Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2010, vol. 16, book 3
Subject Collection: Medicine
Page: 78 - 82
DOI: 10.5272/jimab.1632010_78
Online date: March 23, 2011
INTIMA-MEDIA THICKNESS OF THE COMMON CAROTID ARTERY AND LDL-R DEFECT IN ASYMPTOMATIC SEVERE HYPERCHOLESTEROLEMIA
Lyudmila G. Vladimirova-Kitova
Clinic of Cardiology, Medical University Plovdiv, Bulgaria
ABSTRACT:
The data on the examination of early vascular alterations in carriers of molecular defects of the LDL-R in comparison to non-carriers with severe hypercholesterolemia are controversial. Aim: To examine the difference between patients with severe hypercholesterolemia, who are carriers and non-carriers of LDL-R defective gene, with respect to their structural (intima-media thickness of carotid artery) characteristics of arterial wall. A total of 60 hypercholesterolemic patients were enrolled. Biochemistry parameters were examined by routine methods. Determination of intima-media thickness of common carotid artery was performed with Hewlett Packard Sonos 5 500, using automated computer software MedicaSoft. IMT.lab. Results: There was no significant difference between the groups with respect to total cholesterol, LDL, HDL, triglycerides. We were founded a significantly higher carotid IMT in the carriers versus non-carriers. This significant difference was confirmed after adjustment for age and gender. Conclusion: Our data demonstrate that carriers of the LDL-R defective gene have a higher carotid IMT than non-carriers, whereas no difference between the groups was found with respect to the level of lipid parameters.
Key words: hypercholesterolemia, low-density lipoprotein receptor gene, intima-media thickness, carotis artery.
Page: 78-82; FULL TEXT PDF (137 KB) Abstract
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