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Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312-773X (Online)
Issue: 2010, Volume 16, book 4
DOI: 10.5272/jimab.1642010_67
Subject Collection:Oral and Dental Medicine
Page: 67 - 69
Online date: February 21, 2011
CORTISOL IN SALIVA – A MARKER FOR INCREASED ANXIETY IN CHILDREN
Maya Rashkova1, P. Kalchev2, R. Emilova3, L. Ribagin1, Tz. Doganova4, I. Stoeva3
1 Department of Pediatric Dentistry, Faculty of Dental Medicine, Medical University - Sofia, Bulgaria
2 Department of Psychology, SU “Kliment Ohridski” - Sofia, Bulgaria
3 Institute of Pediatrics, Screening and Fuctional Endocrine Diagnosis Laboratory, Medical University - Sofia, Bulgaria
4 Centre for Dental Medicine - Ruse, Bulgaria
ABSTRACT:
Objectives: Cortisol, called also “stress hormone” participates in organism’s response to stress situations and enters into complex interactions with the hormonal and immune system of a man. The purpose of the study is to follow the cortisol level in saliva as dependent on the anxiety rate in children.
Methods: A screening investigation of 170 children was carried out to evaluate anxiety rate with the help of the revised children’s manifest anxiety scale. 71 children (41 with high and 30 with low anxiety rate) were selected to measure the cortisol in the saliva by ELISA method with Saliva Cortisol Enzyme Immunoassay Kit, product of Salimetrics, USA.
Results: The results show a dependence between the subjective psychological test for anxiety evaluation in infant age and the cortisol in saliva. Saliva is used as a non-invasive diagnostic indicator for the changes in cortisol levels.
Conclusion: Cortisol is an objective oral biomarker that can be used for evaluation of risky oral environment and its connection to the general psychological status of children.
Page: 67-69; FULL TEXT PDF (135 KB) Abstract
REFERENCES:
1. Tabak LA. A revolution in biomedical assessment: the development of salivary diagnostics. J Dent Educ. 2001 Dec;65(12):1335-9. [PubMed]
2. Malamud D, Tabak LA, Saliva as a diagnostic fluid. Ann NY Acad Sciences 1993; 1-694.
3. Gozansky, W.S., Lynn, J.S., Laudenslager, M.L., and Kohrt, W.M. Salivary cortisol determined by enzyme immunoassay is preferable to serum total cortisol for assessment of dynamic hypothalamic-pituitary-adrenal axis activity. Clin Endocrinol (Oxf), 2005, 63,3, 336-41. [PubMed]
4. Schwartz, E. B., Granger, D. A., Susman, E. J., Gunnar, M. R., Laird, B. (1998). Assessing salivary cortisol in studies of child development. Child Development, 1998, 69,6, 1503-1513. [CrossRef]
5. Johnson, L.R., ed. Essential Medical Physiology, 3rd ed. San Diego, Elsevier Academic Press, 2003, pp. 499-502.
6. Hans Selie - Stress without distress, 1982 ed. Science and art,135 pages
7. Cohen, S., R.C. Kessler and L.U. Gordon, Measuring Stress: A Guide for Health and Social Scientists,Oxford: 1997,Oxford University Press. [CrossRef]
8. Ilana Eli - Oral Psychophysiology: Stress, Pain, and Behavior in Dental Care, 214 p;
9. Breivik T, Thrane PS, Murison R, Gjermo P. Emotional stress effects on immunity, gingivitis and periodontitis. Eur J Oral Sci. 1996 Aug;104(4 ( Pt 1)):327-34. [PubMed]
10. Brewer-Smyth, K., Wolbert-Burgess, A., & Shults, J. Physical and sexual abuse, salivary cortisol, and neurologic correlates of violent criminal behavior in female prison inmates. Biological Psychiatry, 2004,55(1), 21-31. [CrossRef] [PubMed]
11. Andrews RC, Herlihy O, Livingstone DE, Andrew R, Walker BR. Abnormal cortisol metabolism and tissue sensitivity to cortisol in patients with glucose intolerance. J Clin Endocrinol Metab. 2002 Dec; 87(12):5587-93. [CrossRef] [PubMed]
12. Epel ES, McEwen B, Seeman T, et al. Stress and body shape: stress-induced cortisol secretion is consistently greater among women with central fat. Psychosom Med. 2000 Sep-Oct;62(5):623-32. [PubMed]
13. Kalchev p. Scale for anxiety in childhood and adolescence, 2006 ed. East West pages 258
14. Reynolds CR, Richmond BO. What I think and feel: a revised measure of children's manifest anxiety. J Abnorm Child Psychol. 1978 Jun;6(2):271-80. [PubMed]
15. Salimetrics/Products and Services [Internet] Available from: http://www.salimetrics.com/