back to 2007, vol. 13, b. 1
Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2007, vol. 13, book 1
Subject Collection: Medicine
Page: 31-34
DOI: 10.5272/jimab.2007131.29
Online date: September 10, 2007

J of IMAB 2007; 13(1):31-34
Galya I. Gancheva, Maria Atanasova, Penka Ilieva,
Department of Infectious Diseases, Epidemiology, Parasitology and Tropical Medicine; Medical University, Pleven, Bulgaria

Serum levels of electrolytes (sodium, chlore, potassium and ionized calcium) in ninety four cases of leptospirosis have been investigated dynamically with routine laboratory methods. Twenty six cases had been with mild course (27,66%), thirty eight with moderate (40,43%), and thirty with severe leptospirosis (31,91%) (р>0,1). The comparison of different serum levels (decreased, normal and increased) of the electrolytes and their averages have revealed significantly increasing only of sodium average before discharge (p<0,05). Analysis of the percentage of cases with different serum levels (normal, below and above normal) of electrolytes in different severity of the disease has been found significantly higher occurrence of hyponatriemia in moderate and severe leptospirosis (p<0,05). Decreased serum levels of ionized calcium have been established in thirteen cases, twelve of them with severe leptospirosis (p<0,05). The dynamical control on the serum levels of sodium, chlore, and potassium have not revealed significant differences in percentage of the disorders (p>0,05). Marked prevalence of the cases with decreased ionized calcium during the hospital period has been observed (p<0,02). In conclusion: electrolytic disorders have not been significant for diagnosis of leptospirosis because they have been observed in ARF independent of the etiology but they have been important for evaluation of the severity and correct treatment of the disease.

Key words: leptospirosis, acute renal failure, serum electrolytes, sodium, chlore, potassium, ionized calcium.

- Download FULL TEXT (PDF - 648 KB)
Please cite this article as:
Gancheva GI, Atanasova M, Ilieva P. SERUM ELECTROLYTES IN LEPTOSPIROSIS. J of IMAB. 2007; 13(1):31-34. doi: 10.5272/jimab.2007131.29

1. Atanasova M. Acute pancreatitis. Published Center MU - Pleven, 2005, 88. (in Bulgarian).
2. Abdulkader RC, Seguro AC, Malheiro PS, Burdmann EA, Marcondes M. Peculiar electrolytic and hormonal abnormalities in acute renal failure due to leptospirosis. Am J Trop Med Hyg. 1996 Jan; 54(1): 1-6. [PubMed]
3. Atanasova M, Gancheva G, Ilieva P, Tzvetanova Chr, Simova I. Pancreatic Involvement in Leptospirosis. J of IMAB. 2005 11(1):13-14,
4. Berezovskaia ZB, Mishshuk II, Ossovskaia AB, Kochetova MV, Poberezhets SIu, Advashkova IA. The characteristics of the course and treatment of severe forms of leptospirosis. Lik Sprava. 1994 Feb;(2):84-5. (in Russian) [PubMed
5. Cengiz K, Sahan C, Sunbul M, Leblebicioglu H, Cuner F. Acute renal failure in leptospirosis in the black-sea region in Turkey. Int Urol Nephrol. 2002 33(1):133-6. [PubMed] [CrossRef]
6. Cetin BD, Harmankaya O, Hasman H, Gunduz A, Oktar M, Seber E. Acute renal failure: a common manifestation of leptospirosis. Ren Fail. 2004 Nov; 26(6): 655-61. [PubMed]
7. Covic A., Goldsmith D.J., Gusbeth-Tatomir P., Seica A., Covic M. A retrospective 5-year study in Moldova of acute renal failure due to leptospirosis: 58 cases and review of the literature. Nephrol Dial Transplant. 2003 Jun; 18(6): 1128-34. [PubMed] [CrossRef]
8. Gancheva G. Complex studies in leptospirosis. Dissertation, 2007, 19, 137-144. (in Bulgarian). 
9. Gancheva G, Ilieva P, Atanasova M, Tzvetanova Chr, Simova I. Tanatogenesis in Leptospirosis. J of IMAB. 2005 11(1):15-16,
10. Gancheva G, Ilieva P, Atanasova M, Tzvetanova Chr, Simova I. Hemo­diaperfusion in Leptospirosis. J of IMAB. 2005 11(1):11-12,
11. Golubic D, Markotic A. Lepto­spi­rosis and hemorrhagic fever with renal syndrome in northwestern Croatia. Acta Med Croatica. 2003 57(5):369-72. (in Croatian) [PubMed]    
12. Yang HY, Hsu PY, Pan MJ, Wu MS, Lee CH, Yu CC, et al. Clinical distinction and evaluation of leptospirosis in Taiwan – a case control study. J Nephrol. 2005 Jan-Feb;18(1):45-53. [PubMed]
13. Younes-Ibrahim M, Buffin-Meyer B, Cheval L. Burth P, Castro-Faria MV, Barlet-Bas C, et al. Na, K-ATPase: a molecular target for Leptospira interrogans endotoxin. Braz J Med Biol Res. 1997 Feb;30(2):213-223. [PubMed]
14. Zhukova LI, Mel’nik GV. Clinical and pathogenic evaluation of acid-base, gas and electrolyte homeostasis in patients with leptospirosis and acute renal insufficiency. Lik Sprava. 2002; (2):43-46. (in Russian). [PubMed]

back to Online Journal