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Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2006, Volume 12, issue 1
DOI: 10.5272/jimab.2006121
Subject Collection: Medicine
Page: 3-50
Date of close: 05 May 2007
CONTENTS: (PDF 482)
J of IMAB 2006; 12(1):3-6; DOI: 10.5272/jimab.2006121.3
THE EFFECT OF ERBISOL ON PRODUCTION OF IL-1β AND NITRIC OXIDE (NO) BY CELLS OF IMMUNE SYSTEM IN PATIENTS WITH CHRONIC UROGENITAL CHLAMYDIOSIS IN VITRO.
Valentyna I. Fesenkova, Georgiy N. Drannik, V. E. Driyanska, V. V. Kologrimova.
Ukrainian Research Center of Immunology Institute of Urology,
National Academy of Medical Science of Ukraine, Kyiv, Ukraine
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J of IMAB 2006; 12(1):7-10; DOI: 10.5272/jimab.2006121.7
MYCOPHENOLATE MOFETIL IN TREATMENT OF CHRONIC GLOMERULONEPHRITIS.
Liliya O. Zub
Institute of Nephrology, Kyiv, Ukraine
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J of IMAB 2006; 12(1):11-15; DOI: 10.5272/jimab.2006121.11
CHARACTERISTICS OF ERYTHROMYCIN-RESISTANT CLINICAL ISOLATES OF STREPTOCOCCUS PYOGENES
Antoaneta Decheva1, V. Karjeva1, D. Beshkov1, I. Alexiev1, Simona Bianco2, Daniela Savoia2
1) National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria.
2) Department of Clinical and Biological Sciences, University of Torino, Italy.
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J of IMAB 2006; 12(3):16-18;
SKIN SIGNS OF A PATIENT WITH T-CELL NHL
Stoyan Pavlov, Vl. Gerov**, St. Racheva, M. Slavova
Department of Dermatology and Venerology, * Department of Hematology, Medical University – Varna, Bulgaria
RESUME:
T-cell non-Hodgkin lymphomas (NHLs) are uncommon malignances that represent approximately 12% of all lymphomas. The most common extranodal sites for NHL are the gastrointestinal tract and nasopharynx; other common sites include skin, brain, bone, thyroid, breast, lung, and testis.
We presented 50 years male patient with peripheral CD30+Tcell NHL with skin and liver involvement. The diagnosis was made on the base of clinicopathologic and immunophenotypic examination.
When the treatment was conducted, the patient responds to systemic chemotherapy with resolving of skin nodules and liver infiltrates.
Our case illustrates that even in secondary cutaneous lymphomas, skin manifestations may be the first sign of systemic disease, and a diagnosis may be achieved on examination of specimens of a cutaneous lesion.
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J of IMAB 2006; 12(1):19-21;
A CASE OF CERVICOFACIAL АCTINOMYCOSIS
St. Racheva, Zh. Dimitrova, St. Pavlov, Zl. Lolev
Department of Dermatology and Venerology, Medical University – Varna, Bulgaria
RESUME:
The Аctinomycosis in humans is rarely observed in Europe. It is presented as a chronic, suppurative, granulomatous infection, originally caused by Actinomyces israelii (found as normal microflora in the mouth cavity) and dependent on the associative bacterial flora.
The most frequent form of Аctinomycosis in humans is the Cervicofacial, followed by the thoracal, abdominal etc.
The slow development of the infection, the thick tumorlike nodules which it forms and the abscesses and fistulas usually hinder the diagnosis of the Аctinomycosis and lead to other initial diagnoses – tumors, phlegmons, etc.
Key words: Аctinomycosis, cervicofacial
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J of IMAB 2006; 12(1):22-25;
ETIOLOGY OF COMMON CONTACT DERMATITIS
St. Racheva
Department of Dermatology and Venerology, Medical University Prof. Dr. Paraskev Stoyanov – Varna, Bulgaria
RESUME:
Contact dermatites (allergic and non-allergic) are frequently observed dermatosеs and they pose a serious problem to the dermatologist. They are usually common dermatites, but a considerable number of the cases are occupational dermatites. The clarification of each concrete case is of great significance for a precise therapeutic approach and efficient prophylactics.
The study aimed at etiological and pathogenetic clarification of common contact dermatitis in a group of 210 patients. The clarification was achieved through dynamic clinical study, anamnestic data, and skin tests (epicutaneous tests – chamber method). In 123 patients (58.5%) of all studied patients allergic contact dermatitis was diagnosed, and in 87 patients (41.4%) – irritant contact dermatitis.
The analysis of the received 213 positive epicutaneous tests revealed that detergents are the most frequent allergens (16.43%), followed by metals (15.02%), rubber additives (14.80%), parabens (10.79%), antiseptics (10,32%), formaldehyde (9.38%), and scents (8.92%).
The most frequent irritant etiological agents were detergents (28.73%), followed by soaps (27.58%), additives to rubber (13.79%), acids and bases, organic solvents.
Key words: allergic contact dermatitis, irritant contact dermatitis, contact allergens, contact irritants.
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J of IMAB 2006; 12(1):26-28;
OUR TRAIL IN TREATMENT AND PROPHYLAXIS OF COLD URTICARIA WITH DESLORATADINE
St. Racheva1, P. Drumeva1, F. Georgieva2
1) Department of Dermatology and Venerology, Medical University Prof. Dr. Paraskev Stoyanov – Varna, Bulgaria;
2) Medical University and "St. Anna" Hospital- Varna,
RESUME:
Cold urticaria presents in quite a lot of cases (31%) with physical urticaria. Its effective treatment and prophylaxis are a problem that is solved by using H1 blockers.
Good alternative method nowadays is Desloratadine - Aerius, having maximal effect with minimal risk of adverse reactions.
Our study included 30 patients with different forms of cold urticaria: hereditary cold urticaria – 4 patients, acquired cold urticaria (contact and refectory) – 13 patients, symptomatic cold urticaria (coexisting with viral infections, medicaments, mycoses) - 8 patients, cold cholinergic urticaria – 5 patients.
All the patients were treated with Desloratadine 1 tablet daily till the end of the clinical features. Afterwards all the patients were prophylacted in the following two months with the same medicament.
The results were: the clinical features disappeared in all the patients in the next 2 weeks; the prophylaxis with Desloratadine was effective in 80% of the treated patients. These allow us to make the conclusion that Desloratadine is a good choice in the treatment and prophylaxis of cold urticaria.
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J of IMAB 2006; 12(1):29-32;
IATROGENICALLY INDUCED SARKOMA KAPOSI IN A PATIENT WITH PEMPHIGUS VULGARIS
St. Racheva, St Pavlov, P. Drumeva
Department of Dermatology and Venerology, Medical University Prof. Dr. Paraskev Stoyanov – Varna, Bulgaria
RESUME:
This is a case of iatrogenically induced Sarkoma Kaposi in a 68-year-old patient suffering from Pemphigus vulgaris. The Pemphigus in question is mucous, localized in the mouth cavity, and two years old.
In the course of treatment with parenterally applied corticosteroid products was observed the appearance and dynamic spread of numerous tumor-like formations of Kaposi Sarcoma type on the limbs, torso and face.
The appearance of Kaposi sarcoma as a result of the continuous immunosuppressive therapy with corticosteroids and cytostatics is discussed.
Key words: iatrogenic, Kaposi's sarcoma
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J of IMAB 2006; 12(1):33-37;
TENDENCIES OF THE DYNAMIC AMBIENT POLLUTION AND RESULTING HOSPITALIZATION DUE TO ACUTE CARDIO-VASCULAR DISEASES IN VARNA REGION
T. Dimitrova1, A. Penev2, I. Zlatarov1
1) Department of Hygiene and Disaster Medicine, Prof. Paraskev Stoyanov Medical University of Varna; 2) Intensive Clinic of Cardiology, St. Marina University Hospital of Varna
SUMMARY:
The purpose of the research is to analyze the dynamics of the basic atmosphere pollutants in the city of Varna and the relation to pollution of atmosphere air with ozone, sulfuric dioxide and nitrogen oxides as a risk factor, affecting the frequency of hospitalizations with regards to acute cardiovascular diseases in the city of Varna. A seasonal dynamics of the average diurnal concentration of basic atmosphere pollutants was established. The relative risk of acute myocardial infarct(AMI) increases to a statistically significant value in the days of increasing of ozone concentration with 5 and more µg/m3 , while concentration increase of nitrogen oxides does not increase the risk of AMI and ischemic cardiac disease - unstable angina pectoris (IHD – unstable AP). The researched data indicates the early effect of the ozone exposition and is related to the increased frequency of AMI-related hospitalizations for the same day. The significantly low content of nitrogen oxides and sulfuric dioxide are a likely reason for not establishing a statistically significant relation of the early effects of its effect to the acute coronary incidents.
Key words: ambient air pollution, acute cardio-vascular disease, hospitalization rates
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J of IMAB 2006; 12(1):38-40;
LOW-CONTRAST ACUITY BEFORE AND AFTER SURGERY IN PATIENTS WITH PITUITARY ADENOMA
Nadejda Deleva, Alexandra Tzoukeva, Ara Kaprelyan
Department of Neurology, Prof. Paraskev Stoyanov Medical University of Varna, Bulgaria
SUMMARY:
Background: Pituitary adenomas account for about 10-15% of all surgically and histologically diagnosed intracranial neoplasms. Patients with non-functional pituitary adenomas most frequently demonstrate visual disturbances. The routine neuroophthalmological examination detects most commonly tumor-related loss of visual acuity and visual field or both. Contrast sensitivity (CS) assessment with sine-wave gratings has not been routinely used, but demonstrates a good agreement with low contrast letter chart findings. Recent studies demonstrate that low-contrast Sloan letter charts are the most eligible and often are used in these cases. A special attention is directed to visual function after surgery. Improvement of visual acuity and CS is reported.
Cases report: We present the results of a neuroophthalmological examination in two patients with parasellar pituitary adenoma before and after surgery. The twelve months follow-up of visual dysfunction includes standard Snellen visual acuity and Goldmann perimeters as well as low contrast number visual acuity. For the needs of low-contrast testing we choose standard for Bulgaria number charts, administered monoculary at 3% and 1.5% contrast.
Conclusion: The presented cases indicate that the low contrast acuity tests in patients with parasellar pituitary adenoma are sensitive indicators just like CS yields information for the visual dysfunction when other visual tests are normal. The loss of low contrast visual acuity improved after surgery as did other visual measures, except in cases with significant low contrast deficit at 1.5% contrast.
Key words: pituitary adenoma, low-contrast visual acuity, follow-up
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J of IMAB 2006; 12(1):41-46; DOI: 10.5272/jimab.2006121.41.
CNS GERMINOMA WITH SYNCHRONOUS LESIONS IN THE SUPRASELLAR AND PINEAL REGIONS: CLINICAL, CT AND IMMUNOLOGICAL FOLLOW-UP
Ara G. Kaprelyan1, Nadejda Deleva1, Alexandra Tzoukeva1, B. Balev2, Krassimir T. Metodiev3, George N. Kyuchukov4
1) Department of Neurology; 2) Department of Radiology; 3) Department of Microbiology; 4)Department of Neurosurgery;
Medical University of Varna, Bulgaria
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J of IMAB 2006; 12(1):47-50; DOI: 10.5272/jimab.2006121.47.
Tc-99m MIBI SPECT AND CT NEUROIMAGING IN PATIENT WITH TUMOR-ASSOCIATED POSTOPERATIVE REFRACTORY SEIZURES: IS IT A TUMOR RELAPSE>
Ara G. Kaprelyan1, Nadejda Deleva1, Pavel Bochev2, Anelia Klissarova2, George N. Kyuchukov3, Ivan Dimitrov1
1) Department of Neurology; 2) Department of Radiology and Nuclear medicine; 3) Department of Neurosurgery,
Medical University of Varna, Bulgaria
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Last edition: may 05, 2007